Godbout, Jonathan P.
Jonathan P. Godbout, Ph.D.Assistant Professor
Department of Molecular Virology, Immunology, and Medical Genetics
Contact Information:
2166B Graves Hall, (Office)
2167B Graces Hall (Lab)
333 W. 10th Avenue,
Office Phone: 614-292-7000
Lab Phone: 614-292-5173
Email:godbout.2@osu.edu
Fax: 614-688-5463
Research Interest: Aging, Neuroimmunology, and Behavior
Research Summary:
The elderly are more susceptible to peripheral infections and have increased incidence of neurological complications following these infections including depression, cognitive dysfunction, and potentially the onset of neurological disease. Therefore the research focus of our laboratory is to understand how age-associated changes in the central nervous system impair the functional interaction between the brain and the immune system. Specifically we are interested in delineating how elevated and prolonged exposure to inflammatory cytokines in the aged brain impairs neurotransmitter and neurotrophic signaling pathways to promote these neurobehavioral deficits. We are using an intergrative approach with molecular, cellular, and behavioral techniques to address these issues.
Selected Publication List:
Godbout, J.P. (In Press) Aging and neuroinflammation: a lifetime of psycho-neuro-immune consequences. Neurologic Clinics
Godbout, J.P., Chen, J., Abraham, J., Richwine, A.R., Berg, B.M., Kelley, K.W., and Johnson, R.W. (2005) Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB Journal, May 26th. Aug; 19(10):1329-31. Epub 2005 May 26.
Godbout, J.P., Berg, B.M., Krzyszton, C., and Johnson, R.W. (2005). a-Tocopherol attenuates NFkB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior. Journal of Neuroimmunology. Epub 2005 September 5.
Richwine, A.R., Godbout, J.P., Chen, J., Berg, B.M., Escobar, J., Millard, D.K. and Johnson, R.W. (In press) Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo interleukin-6 production. Brain, Behavior, and Immunity.
Berg, B.M., Godbout, J.P., Chen, J., Kelley, K.W., and Johnson, R.W. (2005) a-Tocopherol and Selenium facilitate recovery from lipopolysaccharide-induced sickness behavior in aged mice. Journal of Nutrition, 135, 1157-1163.
Godbout, J.P., Berg, B.M., Kelley, K.W., and Johnson, R.W. (2004) a-Tocopherol reduces lipopolysaccharide-induced peroxide radical accumulation and interleukin-6 secretion in primary murine microglia and in brain. Journal of Neuroimmunology. 149, 101-109.
Godbout, J.P. and Johnson, R.W. (2004) Review: Interleukin-6 in the Aging Brain. Journal of Neuroimmunology. 147, 141-144.
Berg, B.M., Godbout, J.P., Kelley, K.W., and Johnson, R.W. (2004) a-Tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice. Brain, Behavior, and Immunity. 18, 149-157.
Hartman, M.E., O’Connor J.C., Godbout, J.P., Minor, K.D., Mazzocco, V.R. and Freund, G.G. (2004) Insulin Receptor Substrate-2-Dependent Interleukin-4 Signaling in Macrophages is Impaired in Two Models of Type 2 Diabetes Mellitus, Journal of Biological Chemistry. 279: 28045-28050.
Godbout, J.P., Pesavento, J., Hartman, M.E., Manson, S.R., and Freund, G.G. (2002) Methylglyoxal Enhances Cisplatin-Induced Cytotoxicity By Activating PKCd Journal of Biological Chemistry. 277: 2554-2561.
Godbout, J.P., Cengel, K.A., Cheng, S., Minshall, C., Kelley, K.W., and Freund, G.G. (1999) Insulin activates caspase-3 by a phosphatidylinositol 3’-kinase dependent pathway. Cellular Signalling. 11: 15-23.
Cengel, K.A., Godbout, J.P., and Freund, G.G. (1998) Phophatidylinositol 3’-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase. Biochemical and Biophysical Research Communications. 242: 513-517.
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