Acharya, Samir

Senior Research Scientist

Department of Molecular Virology, Immunology and Medical Genetics Human Cancer Genetics Program

Contact Information:

Office:

996 Biomedical Research Tower
460 W 12th Avenue
Columbus, OH 43210
Ph. (614) 292-4426
samir.acharya@osumc.edu

Research Interests:

Mechanisms and Regulation of Genomic Stability

Publications:

For current publications please visit The National Center for Biotechnology Information's PubMed website at Acharya, Samir

Grierson PM, Lillard K, Behbehani GK, Combs KA, Bhattacharyya S, Acharya S, Groden J. 2011. BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription. Hum Mol Genet. 2012 Mar 1;21(5):1172-83. Epub 2011 Nov 21.

Russell B, Bhattacharyya S, Keirsey J, Sandy A, Grierson P, Perchiniak E, Kavecansky J, Acharya S, Groden J. 2011. Chromosome breakage is regulated by the interaction of the BLM helicase and topoisomerase IIalpha. Cancer Res. 2011 Jan 15;71(2):561-71. Epub 2011 Jan 11.

Acharya S, Patterson K. 2010 Mutations in the conserved glycine and serine of the MutS ABC signature motif affect nucleotide exchange, kinetics of sliding clamp release of mismatch and mismatch repair. Mutat Res. 2010 Feb 3;684(1-2):56-65. Epub 2009 Nov 30.

Acharya S. 2008 Mutations in the signature motif in MutS affect ATP-induced clamp formation and mismatch repair. Mol Microbiol. 2008 Sep;69(6):1544-59. Epub 2008 Jul 30.

Qian J, Sarnaik AA, Bonney TM, Keirsey J, Combs KA, Steigerwald K, Acharya S, Behbehani GK, Barton MC, Lowy AM, Groden J.2008. The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. Gastroenterology. 2008 Jul;135(1):152-62. Epub 2008 Apr 4.

Snowden T, Shim KS, Schmutte C, Acharya S, Fishel R. 2008. hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery. J Biol Chem. 2008 Jan 4;283(1):145-54. Epub 2007 Oct 30.

Acharya, S., Fishel R. 2006. The Mechanism of DNA Mismatch Repair from Bacteria to Human. In DNA Damage Recognition, eds W. Siede, Y.W. Kow and P. Doetsch, pp 463-482.

Snowden T, Acharya S, Butz C, Berardini M, Fishel R. 2004  hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes. Mol Cell. 2004 Aug 13;15(3):437-51.

Acharya S, Foster PL, Brooks P, Fishel R. 2003. The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair. Mol Cell. 2003 Jul;12(1):233-46.