Sheridan, John
John F. Sheridan, Ph.D.
Professor
Division of Oral Biology, College of Dentistry
Joint Appointment
Department of Molecular Virology, Immunology and Medical Genetics
Research Interests:
Viral immunology, regulation of T cell responses during viral infection, cytokine and chemokine gene expression during infection (influenza, herpes simplex and coxsackie viruses). Neuroendocrine-immune interactions; stress-induced modulation of anti-viral immune responses and viral pathogenesis. Aging and the immune response to viral infection. Aging and gene expression during wound healing. Patterns and kinetics of gene expression for cytokines, chemokines and growth factors during cutaneous wound healing.
Research Summary:
The laboratory uses cellular and molecular techniques to study viral pathogenesis, anti-viral immunity and wound healing. An integrative physiological approach is used to study interactions among the nervous, endocrine and immune systems. Animal models of experiment viral infections (including influenza, herpes simplex and coxsackie viruses) have been adapted to study the effect of neuroendocrine responses on cytokine and chemokine gene expression. In addition, the effects of age and stress on gene expression during infection and wound healing are currently being studied in humans and in animal models.
Selected Publications:
Jacob, S., Ghoshal, K., and Sheridan, J.F. Induction of metallothionein by stress and its molecular mechanisms. Gene Expression 7:301-310, 1999.
Padgett, D.A., MacCallum R., Loria R.M., and Sheridan, J.F. AED-induced restoration of responsiveness to influenza vaccination in old mice. J. Gerontology, Biological Sciences 55A: B1-B7, 2000.
Sheridan, J.F., Stark, J.L., Avitsur, R., and Padgett, D.A. Social disruption, immunity and susceptibility to viral infection: role of glucocorticoid insensitivity and nerve growth factor. Annals of the N.Y. Academy of Science. In press, 2000.
Padgett D.A. and Sheridan J.F., Steroid hormone regulation of anti-viral immunity. Annals of the N.Y. Academy of Sciences, In press, 2000.
Sheridan, J.F., Stark, J.L., Avitsur, R., and Padgett, D.A. Social disruption, immunity and susceptibility to viral infection: role of glucocorticoid insensitivity and nerve growth factor. Annals of the N.Y. Academy of Science. In press, 2000.
*Rojas, I.G., Padgett, D.A., Sheridan, J.F., and Marucha, P.M. Stress-induced susceptibility to bacterial infection during cutaneous wound healing. Brain, Behavior and Immunity, In press, 2000.
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