Molecular Virology, Immunology
& Medical Genetics
Molecular Virology, Immunology
& Medical Genetics
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Research Interests: Cellular, biochemical, and molecular mechanisms by which CD4+ T and B lymphocyte activity is regulated by norepinephrine and beta2-adrenergic receptor stimulation. Selected Publications: Kohm, A. and Sanders, V.M. 1999. Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo. J. Immunol. 162:5299-5308. Kohm, A.P., Tang, Y., *Sanders, V.M., and Jones, S.B. (*=equivalent contribution). 2000. Activation of antigen-specific CD4+ Th2 cells and B cells in vivo increases norepinephrine release in the spleen and bone marrow. J. Immunol., 165:725-733. Kasprowicz, D.J., Kohm, A.P., Berton, M. Chruscinski, A.J., Kobilka, B.K., Sharpe, A., and Sanders, V.M. 2000. Stimulation Of The B Cell Receptor, CD86 (B7-2), and The Beta-2-Adrenergic Receptor Intrinsically Modulates The Level Of IgG1 And IgE Produced Per B Cell. J. Immunology, 165: 680-690. Kohm, A.P. and Sanders, V.M. 2000. Norepinephrine: a messenger from the brain to the immune system. Immunology Today, 21: 539-542. Swanson, M.A., Lee, W.T., and Sanders, V.M. 2001. IFN-g Production by Th1 Cells Generated From Naive CD4+ T cells Exposed to Norepinephrine J. Immunology, 166:232-240. Kohm, A.P. and Sanders, V.M. 2001. Norepinephrine and beta-2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. Pharmacological Reviews., 53:487-525. Kohm, A.P., Mozaffarian, A., and Sanders, V.M. 2002. B cell receptor- and beta-2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells. J. Immunology, 168: 6314-22. Podojil, J. and Sanders, V.M. 2003. Mature IgG1 transcription is regulated by CD86 and beta-2-adrenergic receptor stimulation on a B cell. J. Immunol., 170:5143-5151. Podojil, J., Kin, N. and Sanders, V.M. 2004. CD86 and beta2-adrenergic receptor signaling pathways, respectively, increase Oct-2 and OCA-B Expression and binding to the 3'-IgH enhancer in B cells. J. Biol. Chem., 279:23394-404. Podojil, J.P. and Sanders, V.M. 2005. CD86 and Beta2-Adrenergic Receptor Stimulation Regulate B cell Activity Cooperatively. Trends Immunol. 26:180-185. Sanders, V.M. (2006). Interdisciplinary research: noradrenergic regulation of adaptive immunity. Brain Behav Immun. 20:1-8.
Kin, N. and Sanders, V.M. (2006). It takes nerve to tell T and B cells what to do. J. Leuk. Biol., 79:1093-1104 Kin, N. and Sanders, V.M. (2006). CD86 stimulation on a B cell activates the PI3K/Akt and PLCgamma2/PKCalpha/beta signaling pathways. J. Immunol. 176:6727-35. Pongratz,G., McAlees, JW, Conrad, DH, Erbe, RS, Haas, KM, and Sanders. VM. 2006. The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner. J.Immunol., 177:2926-2938. Kin, N and Sanders, V.M. 2007. CD86 regulates IgG1 production via a CD19-dependent mechanism. J. Immunol.,179:1516-1523. . and Sanders, V.M. McAlees, JW and Sanders, VM. 2008. Hematopoietic protein tyrosine phosphatase mediates ß2-adrenergic receptor-induced regulation of p38 MAPK in a B lymphocyte. Mol. Cell. Biol., 29:675-686 |
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