Qianben Wang

Home > Directory > Faculty Directory > Qianben Wang

Assistant Professor

Ph.D. - University of Maryland School of Medicine
Post Doctoral - Dana-Farber Cancer Institute and Harvard Medical School

My laboratory is interested in understanding the molecular pathological mechanisms underlying the development and progression of prostate cancer. The androgen receptor (AR), a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily, plays a critical role in the onset and progression of prostate cancer. Recently, we have mapped AR binding regions in the entire human genome in prostate cancer cells by using genome-wide chromatin immunoprecipitation (ChIP) techniques. Through an integrated analysis of AR binding and gene expression data, we have begun to understand how AR regulates target genes involved in prostate cancer growth. Currently, we are extending our view from transcriptional regulation by AR to wider transcriptional regulations in prostate cancer including studying combinatorial transcriptional regulation by AR, its collaborating transcription factors, and its coactivators. We will also apply global ChIP techniques to clinical samples obtained from different stages of prostate cancer. This would allow identification of critical cis-regulatory sequences contributing to prostate cancer progression.

Recent Publications:

• Taslim C, Chen Z, Huang K, Huang TH, Wang Q*, Lin S*(2012)" Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF" Nucleic Acids Res 2012 Feb 16 Epub ahead of print (*corresponding author)
• Zhao JC, Yu J, Runkle C, Wu L, Hu M, Wu D, Liu JS, Wang Q, Qin ZS, Yu J (2012) "Cooperation between Polycomb and androgen receptor during oncogenic transformation" Genome Res 22(2):322-31. 
• Wu D, Zhang C, Shen Y, Nephew KP, Wang Q (2011) "Androgen receptor-driven chromatin looping in prostate cancer" Trends Endocrinol Metab 22(12):474-80.
• Zhang C, Wang L, Wu D, Chen H, Chen Z, Thomas-Ahner JM, Zynger DL, Eeckhoute J, Yu J, Luo J, Brown M, Clinton SK, Nephew KP, Huang TH, Li W*, Wang Q* (2011) "Definition of a FoxA1 Cistrome That Is Crucial for G1 to S-Phase Cell-Cycle Transit in Castration-Resistant Prostate Cancer" Cancer Res 71(21):6738-6748. ( * corresponding author)
• Wang H, Zhang C, Rorick A, Wu D, Chiu M, Thomas-Ahner J, Chen Z, Chen H, Clinton SK, Chan KK and Wang Q (2011) "CCI-779 Inhibits Cell-Cycle G2/M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability" Cancer Res. 71(14):4866-76.
• Chen Z, Zhang C, Wu D, Chen H, Rorick A, Zhang X and Wang Q (2011) “Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth” EMBO J. 30(12):2405-19.
• Chen CH, Huang PH, Chiu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q and Chen CS (2011) "Energy restriction-mimetic agents induce apoptosis in prostate cancer cells, in part, through epigenetic activation of KLF6 tumor suppressor gene expression" J Biol Chem. 286(12):9968-76. 
• Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR and McDonnell DP (2011) "CaM Kinase Kinase {beta}-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells" Cancer Res. 71(2):528-37.
• Chen Z, Wang L, Wang Q and Li W (2010) "Histone modifications and chromatin organization in prostate cancer" Epigenomics 2(4):551-560.
• Hsu PY, Hsu HK, Singer GA, Yan PS, Rodriguez BA, Liu JC, Weng YI, Deatherage DE, Chen Z, Pereira JS, Lopez R, Russo J, Wang Q, Lamartiniere CA, Nephew KP and Huang TH (2010) "Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping" Genome Res 20(6):733-44.
• He HH, Meyer CA, Shin H, Bailey ST, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M and Liu XS (2010) "Nucleosome dynamics define transcriptional enhancers" Nat Genet 42(4):343-7.
• Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Wu T, et al (2009) "Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer" Cell 138:245-56. (Featured Article).
• Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP (2009) "Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro" Mol Endocrinol. 23(9):1385-96.
• Sun T, Wang Q, Balk SP, Brown M, Lee GS and Kantoff PW (2009) "Roles of microRNA-221 and -222 in castration resistant prostate cancer" Cancer Res 69:3356-63.
• Wang Q and Brown M (2009) "Mapping the androgen receptor cistrome" In Tindall DJ and Mohler JL, eds. Androgen Action in Prostate Cancer, New York, NY: Springer Science and Business Media, pp.663-80.
• Nwachukwu JC, Mita P, Ruoff R, Ha S, Wang Q, Huang SJ, Taneja SS, Brown M, Gerald WL, Garabedian MJ and Logan SK (2009) "Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells" Cancer Res 69(7):3140-7.
• Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Carroll JS, Liu XS, and Brown M (2008) "FoxA1 translates epigenetic signatures into lineage-specific transcription" Cell 132:958-70.
• Bao BY, Chuang BF, Wang Q, Kantoff PW, Brown M, Sartor O, and Lee GS (2008) "Regulation of UGT2B15/17 by androgen signaling in prostate cancer cells" Prostate 68:839-48.
• Agoulnik IU, Bingman WE 3rd, Nakka M, Li W, Wang Q, Liu XS, Brown M, Weigel NL (2008) "Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase" Mol Endocrinol 22: 2420-32.
• Wang Q, Li W, Liu XS, Carroll JS, Jänne OA, Keeton EK, Chinnaiyan AM, Pienta KJ and Brown M (2007) "A hierarchical network of transcription factors governs androgen receptor dependent prostate cancer growth" Mol Cell 27:380-92 (Featured Article).
• Wang QF, Prabhakar S, Wang Q, Moses AM, Chanan S, Brown M, Eisen MB, Cheng JF, Rubin EM, and Boffelli D (2006) "Primate-specific evolution of an LDLR enhancer" Genome Biol 7: R68.
• Carroll JS, Meyer CA, Song J, Li W, Brodsky AS, Geistlinger TR, Eeckhoute J, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS and Brown M (2006) "Genome wide analysis of estrogen receptor binding sites" Nat Genet 38:1289-97.
• Wang Q, Carroll JS and Brown M (2005) "Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking" Mol Cell 19:631-42.
• Wang Q, Udayakumar TS, Vasaitis TS, Brodie AH and Fondell JD(2004) "Mechanistic relationship between androgen receptor polyglutamine tract truction and androgen-dependent transcriptional hyperactivity in prostate cancer cells" J Biol Chem 279:17319-28.
• Wang Q, Dipali S, Ren Y and Fondell JD (2002) "A coregulatory role for the TRAP-Mediator complex in androgen receptor-mediated gene expression" J Biol Chem 277:42852-58